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Eyfem (Ophthalmic Suspension & Ointment)

 

COMPOSITION

Eye Drops:
Each ml contains:
Fluorometholone U.S.P. ……………………. 1.0 mg.
with: Benzalkonium chloride 0.004%, sodium chloride, edetate disodium, polysorbate 80, polyvinyl alcohol 14 mg and purified water.
Ophthalmic Ointment:
Each gm contains:
Fluorometholone U.S.P. ……………………. 1.0 mg.
with: Mineral oil & white petrolatum.
DESCRIPTION: Fluorometholone (Eyfem) is a glucocorticoid employed as eye drops/ointment containing 0.1% in the treatment of allergic and inflammatory conditions of the eye.

CLINICAL PHARMACOLOGY

Fluorometholone has 40 times powerful anti-inflammatory action than hydrocortisone. Like all anti- inflammatory glucocorticoids, fluorometholone inhibits phospholipase A2, the first stage in prostaglandin synthesis. Fluorometholone also inhibits the chemotactic migration of neutrophilic cells into the focus of inflammation. In contrast to other topical glucocorticoids, fluorometholone has an anti-inflammatory action without significantly influencing the intraocular pressure. The immunosuppressive action of fluorometholone is less pronounced than that of dexamethasone. With a single administration of fluorometholone eye drops in the eye, maximum concentrations of 1.5